Human MHC architecture and evolution: implications for disease association studies
作者： J. A. Traherne
DOI: 10.1111/J.1744-313X.2008.00765.X
关键词:
摘要: Major histocompatibility complex (MHC) variation is a key determinant of susceptibility and resistance to large number infectious, autoimmune other diseases. Identification the MHC variants conferring disease problematic, due high levels linkage disequilibrium. Recent cataloguing analysis over complete has facilitated localization loci for diseases, provided insight into MHC's evolution. This review considers how unusual genetic characteristics impact on strategies identify causing, or contributing to, phenotypes. It also in relation novel mechanisms influencing gene function regulation, such as epistasis, epigenetics microRNAs. These developments, along with recent technological advances, shed light association disease.
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