Regulatory network analysis of high expressed long non-coding RNA LINC00941 in gastric cancer.
作者： Cong Luo , Yang Tao , Yuwei Zhang , Yinyin Zhu , Derry Ng Minyao
DOI: 10.1016/J.GENE.2018.04.023
关键词:
摘要: Accumulating evidence suggests that the aberrant expression of long non-coding RNAs is closely related to carcinogenesis and progression gastric cancer (GC), which a type prevalent tumor with high incidence mortality rate. However, it still challenge find reliable biomarkers understand their molecular mechanisms in GC. In this study, we first confirmed LINC00941was up-regulated GC tissues compared adjacent normal by RT-PCR, found level LINC00941 was correlated invasion depth, lymphatic metastasis, TNM stage patients Furthermore, performing enrichment analysis based on co-expression network regulatory network, associated biological processes such as cell cycle, communication, migration, division, well immune system. Our results suggested may be potential novel biomarker for therapeutic or diagnostic
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