Selection of the chimpanzee over the baboon as a model for Helicobacter pylori infection.

摘要: Baboons (Papio sp.) and chimpanzees (Pan troglodytes) were screened for the presence of Helicobacter pylori. The gastric mucosae baboons colonized by large spiral bacteria. However, a group adult identified that free bacteria, with five animals being recruited into an H. pylori challenge study. These inoculated orogastrically one four strains followed up to 26 weeks. was established in these during primary two other on secondary challenge. It shown chimpanzee can be infected inflammatory response mimics seen humans. Infection marked antibody pylori-specific antigens animals. observed antibody-negative had no apparent infection or related Thus serological screening used identify candidate further evaluation.