Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
作者： Hitoshi Matsushime , Mark E. Ewen , David K. Strom , Jun-Ya Kato , Steven K. Hanks
DOI: 10.1016/0092-8674(92)90360-O
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摘要: Abstract Murine D type cyclins associate with a catalytic subunit (p34 PSK-J3 ) properties distinct from known cyclin-dependent kinases (cdks). Mouse p34 shows less than 50% amino acid identity to cdc2 , p33 cdk2 and p36 cdk3 lacks PSTAIRE motif, does not bind p13 suc1 . Cyclin D1-p34 complexes accumulate in macrophages during G1 decline S phase, whereas involving D2 D3 form proliferating T cells. Although histone H1 kinase activity is detected cyclin or immunoprecipitates, D-p34 assembled vitro stably phosphorylate the retinoblastoma gene product (pRb) an Rb-like protein (p 107) but do interact pRb mutants that are functionally inactive. Thus, D-regulated acts as Rb (but H1) kinase.
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sci-hub.se 参考文章(59)
K.L. Gould, S. Moreno, D.J. Owen, S. Sazer, P. Nurse, Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. The EMBO Journal. ,vol. 10, pp. 3297- 3309 ,(1991) , 10.1002/J.1460-2075.1991.TB04894.X
Matthew Meyerson, Greg H Enders, Chin-Lee Wu, LK Su, C Gorka, C Nelson, Ed Harlow, LH Tsai, A family of human cdc2-related protein kinases. The EMBO Journal. ,vol. 11, pp. 2909- 2917 ,(1992) , 10.1002/J.1460-2075.1992.TB05360.X
R. Nash, G. Tokiwa, S. Anand, K. Erickson, A. B. Futcher, The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. The EMBO Journal. ,vol. 7, pp. 4335- 4346 ,(1988) , 10.1002/J.1460-2075.1988.TB03332.X
M. Pagano, R. Pepperkok, F. Verde, W. Ansorge, G. Draetta, Cyclin A is required at two points in the human cell cycle. The EMBO Journal. ,vol. 11, pp. 961- 971 ,(1992) , 10.1002/J.1460-2075.1992.TB05135.X
Summers, G.E. Smith, A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures. Bulletin B - Texas Agricultural Experiment Station (USA). ,vol. 1555, pp. 56- 56 ,(1987)
S J Anderson, M A Gonda, C W Rettenmier, C J Sherr, Subcellular localization of glycoproteins encoded by the viral oncogene v-fms. Journal of Virology. ,vol. 51, pp. 730- 741 ,(1984) , 10.1128/JVI.51.3.730-741.1984
Q J Hu, C Bautista, G M Edwards, D Defeo-Jones, R E Jones, E Harlow, Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Molecular and Cellular Biology. ,vol. 11, pp. 5792- 5799 ,(1991) , 10.1128/MCB.11.11.5792
J R Downing, C W Rettenmier, C J Sherr, Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line. Molecular and Cellular Biology. ,vol. 8, pp. 1795- 1799 ,(1988) , 10.1128/MCB.8.4.1795
C H McGowan, P Russell, S I Reed, Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle. Molecular and Cellular Biology. ,vol. 10, pp. 3847- 3851 ,(1990) , 10.1128/MCB.10.7.3847
J. Rosenblatt, Y. Gu, D. O. Morgan, Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 2824- 2828 ,(1992) , 10.1073/PNAS.89.7.2824