High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies

摘要: Summary Objective  This study is the first to report high molecular weight (HMW) adiponectin in newborns from normal and pre-eclamptic pregnancies (PE). Adiponectin adversely related Metabolic Syndrome-linked diseases such as obesity, dyslipidaemia, insulin resistance hypertension. It abundant human plasma where it circulates several characteristic multimeric forms of which HMW form most active. As children PE-pregnancies have a greater susceptibility hypertensive disorders later life, we hypothesized that measured cord blood could be putative risk marker. Design patients  Cross-sectional, hospital-based mothers with pre-eclampsia (30 cases 62 controls). Venous samples were collected immediately after birth analysed for total adiponectin. Measurements  Total by commercially available enzyme-linked immunosorbent assay (ELISA) kits. Results  The PE showed significantly lower gestational age (GA), levels than controls. No differences found between case control groups when correcting GA. In combined groups, log (total adipo) = 0·40 + 0·027*GA; r = 0·43, P < 0·001. Furthermore, dominant adiponectin: adipo = –5·06 + 0·81*total adipo; r = 0·90, P < 0·001. Conclusions  may not tentative marker diseases. blood. Its role during pregnancy postnatal life should further explored.