Application of built-in adjuvants for epitope-based vaccines

摘要: Several studies have shown that epitope vaccines exhibit substantial advantages over conventional vaccines. However, are associated with limited immunity, which can be overcome by conjugating antigenic epitopes built-in adjuvants (e.g., some carrier proteins or new biomaterials) special properties, including immunologic specificity, good biosecurity and biocompatibility, the ability to vastly improve immune response of When designing vaccines, following types typically considered: (1) pattern recognition receptor ligands (i.e., toll-like receptors); (2) virus-like particle platforms; (3) bacterial toxin proteins; (4) novel potential delivery systems self-assembled peptide nanoparticles, lipid core peptides, polymeric inorganic nanoparticles). This review primarily discusses current prospective applications these biological carriers) provide references for future design epitope-based