Virus-like particle vaccines and adjuvants: the HPV paradigm

摘要: Complex antigen structures currently represent the most-studied approach for prophylactic as well therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on nature viral pathogen they are trying to replicate (enveloped vs naked) or modality express antigenic epitopes (i.e., binding envelope protein liposomic structures). The structure these vaccines provides them with some adjuvanted properties, not uniformly present all particle types. further inclusion specific adjuvants in vaccine preparations can modify presentation such immune system a Th1 versus Th2 polarization efficacy. A paradigm relevance new immunological results obtained monophosphoryl lipid adjuvant formulation L1-based human papillomavirus-naked reduce cellul...