Cutting edge: OFF cycling of TNF production by antigen-specific CD8+ T cells is antigen independent.
作者： Vladimir P. Badovinac , Gail A. Corbin , John T. Harty
DOI: 10.4049/JIMMUNOL.165.10.5387
关键词:
摘要: Although they are known for their capacity to kill infected cells, Ag-specific CD8 + T cells elaborate other effector mechanisms, including TNF and IFN-γ, that contribute defense against infection. rapidly turn ON OFF IFN-γ production in direct response Ag contact, presumably minimize the potential immunopathology could result from inappropriate secretion of this inflammatory mediator. In study, we show, using vitro propagated directly ex vivo-analyzed contrast Ag-dependent ON/OFF cycling production, cessation by same producing is rapid independent.
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