Distinct molecular signatures in pediatric infratentorial glioblastomas defined by aCGH

摘要: Glioblastomas (GBM) are rare in children, but reportedly have more varied outcome which suggests differences tumor etiology compared to typical GBM of adults. To investigate this we performed high resolution array comparative genomic hybridization (aCGH) analysis on three pediatric infratentorial GBM, ages 3.5, 7 and 14 years. Two these tumors occurred the brainstem one spinal cord. While histologically typical, showed mainly pleomorphic astrocytic cells, whereas other a GFAP positive small cell component. Whole chromosomal gains (#1 #2) loss (#20) were seen only also level segmental copy number changes. Segmental involving chromosome 8 was all (Chr8;133039446-136869494, Chr8;pter-3581577, Chr8;pter-30480019 respectively), 16 2 cases with components (Chr16;31827239-qter Chr16;pter-29754532). gain shared between (Chr7;17187166-qter Chr7;69824947-qter). Chromosome 17 17q backdrop 17p case 1. 1q 2. The relatively stable karyotype unique Chr19;32848902-qter. None frequent losses, amplifications known occur adult identified, suggesting that glioblastomas show molecular characteristic embryonal than GBM.