Protective effects of adenosine receptor agonist in a cirrhotic liver resection model

摘要: Objectives: To investigate the role of CGS21680, a selective adenosine A2A receptor agonist, on bile-duct-ligated cirrhotic liver resection model in rats. Methods: Male Wistar rats were allotted into 3 groups (n = 7 per time-point): control group, bile duct ligation + CGS21680 group (BDL CGS), and (BDL). Biliary cirrhosis had been previously induced by ligature common BDL CGS groups. After 2 weeks, animals underwent partial hepatectomy (50%). The received single dose 15 minutes prior to hepatectomy. Blood samples collected analyzed. Results: Aspartate transaminase levels found be lower vs (1, 3, 24 h) (P < 0.01) (1 hours) (24 0.05) Hepatic flow was measured showed significantly values at 24, 168 h time-points compared 0.05 hours; P 0.01 h). O2C velocity reduced 0.001 hours). Interleukin-6 abrogated versus BDL. Histone-bound low-molecular-weight DNA fragments low group. Conclusions: Administration an after livers led improved function, regeneration, microcirculation.