Base compositional structure of genomes

摘要: Abstract We model the base compositional structure of human and Escherichia coli genomes. Three particular properties are first quantified: (1) There is a significant tendency for any region either genome to have strand-symmetric composition. (2) The variation in composition from region, within each genome, very much larger than expected common homogeneous stochastic models. (3) A given local tends persist over scale at least kilobases ( E. ) or tens (human). Multidomain models literature reviewed sharpened. In particular, quantitative measurements third property lead us suggest shift style domain models, which + T content with position modeled by random walk frequent small steps rather large quantum jumps. As an application, we way reduce amount computation assembly sequences randomly chosen fragments.