Therapeutic antibody targeting of individual Notch receptors
作者： Yan Wu , Carol Cain-Hom , Lisa Choy , Thijs J. Hagenbeek , Gladys P. de Leon
DOI: 10.1038/NATURE08878
关键词:
摘要: The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and …
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Brian J. Nickoloff, Richard E.B. Seftor, Jeffrey M. Trent, Lawrence Stennett, Pamela M. Pollock, Amy Curtis, Mary J.C. Hendrix, Naira V. Margaryan, Barbara Bodner, Lucio Miele, Frank Bennett, Patricia Bacon, Elisabeth A. Seftor, Jian Zhong Qin, p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. Molecular Cancer Therapeutics. ,vol. 3, pp. 895- 902 ,(2004)
Chingwei V Lee, Wei-Ching Liang, Mark S Dennis, Charles Eigenbrot, Sachdev S Sidhu, Germaine Fuh, High-affinity Human Antibodies from Phage-displayed Synthetic Fab Libraries with a Single Framework Scaffold Journal of Molecular Biology. ,vol. 340, pp. 1073- 1093 ,(2004) , 10.1016/J.JMB.2004.05.051
G. Troen, I. Wlodarska, A. Warsame, S. Hernandez Llodra, C. De Wolf-Peeters, J. Delabie, NOTCH2 mutations in marginal zone lymphoma. Haematologica. ,vol. 93, pp. 1107- 1109 ,(2008) , 10.3324/HAEMATOL.11635
Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos, Gavin Thurston, Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis Nature. ,vol. 444, pp. 1032- 1037 ,(2006) , 10.1038/NATURE05355
Raphael Kopan, Ma. Xenia G. Ilagan, The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism Cell. ,vol. 137, pp. 216- 233 ,(2009) , 10.1016/J.CELL.2009.03.045
U. Koch, F. Radtke, Notch and cancer: a double-edged sword Cellular and Molecular Life Sciences. ,vol. 64, pp. 2746- 2762 ,(2007) , 10.1007/S00018-007-7164-1
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris IV, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster, Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia Science. ,vol. 306, pp. 269- 271 ,(2004) , 10.1126/SCIENCE.1102160
Kevin G. Leong, Aly Karsan, Recent insights into the role of Notch signaling in tumorigenesis Blood. ,vol. 107, pp. 2223- 2233 ,(2006) , 10.1182/BLOOD-2005-08-3329
P. Carter, L. Presta, C. M. Gorman, J. B. Ridgway, D. Henner, W. L. Wong, A. M. Rowland, C. Kotts, M. E. Carver, H. M. Shepard, Humanization of an anti-p185HER2 antibody for human cancer therapy. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 4285- 4289 ,(1992) , 10.1073/PNAS.89.10.4285
Jörg Kirberg, Anton Berns, Harald von Boehmer, Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules Journal of Experimental Medicine. ,vol. 186, pp. 1269- 1275 ,(1997) , 10.1084/JEM.186.8.1269