摘要: Members of the ErbB (epidermal growth factor receptor) family receptor tyrosine kinases are important in etiology human mammary carcinoma, and rational targets for cancer therapy. The frequent selection ErbB2/HER2/Neu, and, less often, epidermal receptor, ErbB3 overexpression breast implies that these receptors have functions normal development. Better understanding ErbBs development may yield dividends deployment therapies. roles their ligands discussed, with an emphasis on new insights from genetic analysis mice.
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Carolyn I. Sartor, Hong Zhou, Ewa Kozlowska, Katherine Guttridge, Evelyn Kawata, Laura Caskey, Jennifer Harrelson, Nancy Hynes, Stephen Ethier, Benjamin Calvo, H. Shelton Earp, HER4 Mediates Ligand-Dependent Antiproliferative and Differentiation Responses in Human Breast Cancer Cells Molecular and Cellular Biology. ,vol. 21, pp. 4265- 4275 ,(2001) , 10.1128/MCB.21.13.4265-4275.2001
Wolfgang F. Vogel, Attila Aszódi, Frauke Alves, Tony Pawson, Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Molecular and Cellular Biology. ,vol. 21, pp. 2906- 2917 ,(2001) , 10.1128/MCB.21.8.2906-2917.2001
J. A. Drebin, V. C. Link, R. A. Weinberg, M. I. Greene, Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 9129- 9133 ,(1986) , 10.1073/PNAS.83.23.9129
Mien Chie Hung, Dihua Yu, Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells. Oncogene. ,vol. 6, pp. 1991- 1996 ,(1991)
Catherin Niemann, 1,2Volker Brinkmann, Walter Birchmeier, Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis. Advances in Experimental Medicine and Biology. ,vol. 480, pp. 9- 18 ,(2002) , 10.1007/0-306-46832-8_2
Frank E Jones, David F Stern, Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation. Oncogene. ,vol. 18, pp. 3481- 3490 ,(1999) , 10.1038/SJ.ONC.1202698
J M Knowlden, J M W Gee, L T Seery, L Farrow, W J Gullick, I O Ellis, R W Blamey, J F R Robertson, R I Nicholson, c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer. Oncogene. ,vol. 17, pp. 1949- 1957 ,(1998) , 10.1038/SJ.ONC.1202107
Timothy J Gulliford, Guo Cai Huang, Xiaomei Ouyang, Richard J Epstein, Reduced ability of transforming growth factor-alpha to induce EGF receptor heterodimerization and downregulation suggests a mechanism of oncogenic synergy with ErbB2. Oncogene. ,vol. 15, pp. 2219- 2223 ,(1997) , 10.1038/SJ.ONC.1201595
Li Li, Siobhan Cleary, Michael A Mandarano, Weiwen Long, Carmen Birchmeier, Frank E Jones, The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland. Oncogene. ,vol. 21, pp. 4900- 4907 ,(2002) , 10.1038/SJ.ONC.1205634
King L, Cohen S, Carpenter G, Epidermal growth factor-receptor-protein kinase interactions. Progress in Clinical and Biological Research. pp. 557- 567 ,(1981)