Genetic polymorphisms of the human MDR1 drug transporter
作者： Matthias Schwab , Michel Eichelbaum , Martin F. Fromm
DOI: 10.1146/ANNUREV.PHARMTOX.43.100901.140233
关键词:
摘要: P-glycoprotein is an ATP-dependent efflux pump that contributes to the protection of body from environmental toxins. It transports a huge variety structurally diverse compounds. involved in limiting absorption xenobiotics gut lumen, sensitive tissues (brain, fetus, testis), and biliary urinary excretion its substrates. can be inhibited or induced by xenobiotics, thereby contributing variable drug disposition interactions. Recently, several SNPs have been identified MDR1 gene, some which affect expression function. Potential implications polymorphisms for disposition, effects, disease risk are discussed.
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