Molecular and cellular aspects of the insulin-like growth factor I receptor
作者： DEREK LEROITH , HAIM WERNER , DANA BEITNER-JOHNSON , ANDCHARLES T. ROBERTS
关键词:
摘要: I. Introduction THE insulin-like growth factors (IGFs) and their receptors binding proteins constitute a family of cellular modulators that play essential roles in the regulation development. The IGF ligands include three structurally related peptides: insulin, IGF-I, IGF-II. Unlike IGF-I IGF-II are expressed ubiquitously, albeit highly regulated manner (see reviews Refs. 1-5). biological functions IGFs mediated by transmembrane receptors, which includes IGF-II/mannose-6-phosphate (M-6-P) receptors. While receptor is primary mediator action, insulin IGF-II/M-6-P may also mediate some these (Fig. 1) (6, 7). actions modulated at least six IGF-binding (IGFBPs) found circulation extracellular compartments produced most tissues. IGFBPs capable inhibiting or enhancing I...
oup.com
elsevier.com
endojournals.org参考文章(269)
Jian Zhou, Carolyn Bondy, Anatomy of the insulin-like growth factor system in the human testis Fertility and Sterility. ,vol. 60, pp. 897- 904 ,(1993) , 10.1016/S0015-0282(16)56294-3
E L Germain-Lee, M Janicot, R Lammers, A Ullrich, S J Casella, Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II. Biochemical Journal. ,vol. 281, pp. 413- 417 ,(1992) , 10.1042/BJ2810413
T.N. Faria, V.A. Blakesley, H. Kato, B. Stannard, D. LeRoith, C.T. Roberts, Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. Journal of Biological Chemistry. ,vol. 269, pp. 13922- 13928 ,(1994) , 10.1016/S0021-9258(17)36736-4
H Yamasaki, D Prager, S Gebremedhin, S Melmed, Human insulin-like growth factor I receptor 950tyrosine is required for somatotroph growth factor signal transduction. Journal of Biological Chemistry. ,vol. 267, pp. 20953- 20958 ,(1992) , 10.1016/S0021-9258(19)36781-X
D. A. Sens, T. S. Gramling, M. G. Buse, R. Furlanetto, T. Gansler, N. Blocker, A. J. Garvin, K. A. Robinson, Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice. American Journal of Pathology. ,vol. 135, pp. 961- 966 ,(1989)
Matthew M. Rechler, Insulin-like growth factor binding proteins. Vitamins and Hormones Series. ,vol. 47, pp. 1- 114 ,(1993) , 10.1016/S0083-6729(08)60444-6
V M Macaulay, M J Everard, I E Smith, J D Teale, J J Van Wyk, P A Trott, J L Millar, Autocrine Function for Insulin-like Growth Factor I in Human Small Cell Lung Cancer Cell Lines and Fresh Tumor Cells Cancer Research. ,vol. 50, pp. 2511- 2517 ,(1990)
Fredrika Pekonen, Tuulikki Mäkinen, Seppo Partanen, Eeva-Marja Rutanen, Receptors for Epidermal Growth Factor and Insulin-like Growth Factor I and Their Relation to Steroid Receptors in Human Breast Cancer Cancer Research. ,vol. 48, pp. 1343- 1347 ,(1988)
AS Andersen, T Kjeldsen, FC Wiberg, H Vissing, L Schäffer, JS Rasmussen, P De Meyts, NP Møller, None, Identification of determinants that confer ligand specificity on the insulin receptor. Journal of Biological Chemistry. ,vol. 267, pp. 13681- 13686 ,(1992) , 10.1016/S0021-9258(18)42267-3