DNA DamageDNA damage and DNA Replication StressDNA replication stress in Yeast Models of Aging

摘要: DNA damage is an important factor in aging all eukaryotes. Although connections between and have been extensively investigated complex organisms, only a relatively few studies as the model organism S. cerevisiae. Several of these point to replication stress cause age-dependent replicative aging, which measures how many times budding yeast cells divide before they senesce die. Even fewer contributes chronological model, long stationary phase cultures retain reproductive capacity. also has implicated . Since are generally considered be “post-mitotic” reside quiescent G0/G1 state, notion that defects might contribute appears somewhat paradoxical. However, results recent suggest significant fraction not quiescent, especially experiments employ defined medium, frequently employed assess lifespan. Most fail achieve quiescence remain viable, but non-dividing state until eventually die, similar senescent mammalian cells. In this chapter we discuss role both We relevance findings emerging view components occurs at early stages cancer.