摘要: Aspirin often causes acute gastric mucosal damage that can be seen endoscopically or assessed indirectly (for example, by measuring increased gastrointestinal blood loss). The occurrence of most adverse effects is apparently related to the dose administered. This dose-response effect, evident in both endoscopic and microbleeding studies done after short-term aspirin administration, also associated with risk developing chronic ulcer. adaptation, lessening injury continued treatment, obscures interpretation results from administration. Moreover, evidence has frequently been ignored when lists complications side are compiled. absence symptoms does not correlate appears have no predictive value. Endoscopic linking extent degree various nonsteroidal anti-inflammatory drugs little value predicting frequency severity ulcer bleeding.
sci-hub.se 参考文章(83)
Morton I. Grossman, Kenneth K. Matsumoto, Raymond J. Lichter, Fecal blood loss produced by oral and intravenous administration of various salicylates. Gastroenterology. ,vol. 40, pp. 383- 388 ,(1961) , 10.1016/S0016-5085(61)80070-X
Hoftiezer Jw, O'Laughlin Jc, Ivey Kj, Effect of aspirin on the human stomach in normals: endoscopic comparison of damage produced one hour, 24 hours, and 2 weeks after administration. Scandinavian Journal of Gastroenterology. ,vol. 67, pp. 211- 214 ,(1981)
Alex Weiss, Ernest R. Pitman, Emerson C. Graham, Aspirin and gastric bleeding The American Journal of Medicine. ,vol. 31, pp. 266- 278 ,(1961) , 10.1016/0002-9343(61)90115-2
G Ekenved, G Dotevall, The absorption of acetylsalicylic acid from the stomach in relation to intragastric pH. Scandinavian Journal of Gastroenterology. ,vol. 11, pp. 801- 805 ,(1976)
Robert Lev, Howard I. Siegel, George B. Jerzy Glass, Effects of salicylates on the canine stomach: a morphological and histochemical study. Gastroenterology. ,vol. 62, pp. 970- 980 ,(1972) , 10.1016/S0016-5085(72)80114-8
Gregory L. Eastwood, G. Forrest Quimby, Effect of Chronic Aspirin Ingestion on Epithelial Proliferation in Rat Fundus, Antrum, and Duodenum Gastroenterology. ,vol. 82, pp. 852- 856 ,(1982) , 10.1016/S0016-5085(82)80245-X
J. Critchlow, D. Magee, S. Ito, K. Takeuchi, W. Silen, Requirements for Restitution of the Surface Epithelium of Frog Stomach After Mucosal Injury Gastroenterology. ,vol. 88, pp. 237- 249 ,(1985) , 10.1016/S0016-5085(85)80177-3
L.Stephen Coles, James F. Fries, R.Guy Kraines, Sanford H. Roth, From experiment to experience: Side effects of nonsteroidal anti-inflammatory drugs The American Journal of Medicine. ,vol. 74, pp. 820- 828 ,(1983) , 10.1016/0002-9343(83)91073-2
P. H. N. Wood, E. A. Harvey-Smith, A. St. J. Dixon, Salicylates and Gastro-intestinal Bleeding BMJ. ,vol. 1, pp. 669- 675 ,(1962) , 10.1136/BMJ.1.5279.669
P.C. Elwood, P.M. Sweetnam, ASPIRIN AND SECONDARY MORTALITY AFTER MYOCARDIAL INFARCTION The Lancet. ,vol. 314, pp. 1313- 1315 ,(1979) , 10.1016/S0140-6736(79)92808-3