Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds

摘要: Avulsion, epidermal marsupialization, and infection cause failure at the skin-material interface. A robust interface would permit implantable robotics, prosthetics, other medical devices; reconstruction of surgical defects, long-term access to blood vessels body cavities. Torus-shaped cap-scaffold structures were designed work in conjunction with negative pressure address three causes failure. Six wounds made on backs each four 3-month old pigs. Four unmodified (no caps) scaffolds implanted along 20 cap-scaffolds. Collagen type 4 was attached 21 implants. Negative then applied. Structures explanted assessed histologically day 7 28. At 28, there close tissue apposition scaffolds, without detectable reactions from defensive or interfering cells. Three cap-scaffolds 28 showed likely attachment epidermis cap junction, deeper marsupialization. The combination toric-shaped appears be an intrinsically biocompatible system, enabling a © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1307-1318, 2017.