EGF receptor targeting in therapy-resistant human tumors.

摘要: The development of resistance against cytotoxic or endocrine therapy limits the number chemotherapeutic compounds used in clinic. receptor for EGF (EGFR) is not only involved survival signaling, cell migration, metastasis formation and angiogenesis, but also confers reduced responses tumor cells towards radiation. Clinical trials designed to combine EGFR inhibitors with standard chemo- radiation have been successful. Elucidation some molecular mechanisms EGFR-mediated chemoresistance may lead novel treatment approaches molecules linked signal transduction. In human breast carcinomas, presence correlates lack response anti-estrogen suggesting concomitant inhibition both receptors estrogen improve cancer therapy.