Polyinosinic-cytidylic acid as an adjuvant on natural killer- and dendritic cell-mediated antitumor activities
作者： Yu-Kun Huang , Zhi Zheng , Fu Qiu
DOI: 10.1007/S13277-013-0693-3
关键词:
摘要: Previously, we demonstrated that treatment with E7(44–62) and the adjuvant polyinosinic-cytidylic acid (poly(I:C)) in a rodent model generates antitumor immune responses, but effect of poly(I:C) on natural killer (NK)- dendritic cell (DC)-mediated activities is still unclear. Our goal was to examine effects poly(I:C). We examined ability induce toll-like receptor 3 (TLR3) expression, tumor necrosis factor-alpha (TNF-α) interferon-gamma (IFN-γ) mRNA cell-killing activity human NK cells as well its CD11c CD86 expression proliferation DCs. found markedly increased TLR3 cytotoxicity against HeLa NK92 cells. Moreover, up-regulated IFN-γ TNF-α Human patients cervical cancer exhibited marked decrease frequency DCs; however, ex vivo restored DC frequency. Stimulation DCs led high levels expression. data reveal involvement combined potentiating cytokine-producing
springer.com
sci-hub.se 参考文章(22)
Zhengrong Cui, Fu Qiu, Synthetic double-stranded RNA poly(I:C) as a potent peptide vaccine adjuvant: therapeutic activity against human cervical cancer in a rodent model Cancer Immunology, Immunotherapy. ,vol. 55, pp. 1267- 1279 ,(2006) , 10.1007/S00262-005-0114-6
Troels R Petersen, Dianne Sika‐Paotonu, Deborah A Knight, Nina Dickgreber, Kathryn J Farrand, Franca Ronchese, Ian F Hermans, Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand Immunology and Cell Biology. ,vol. 88, pp. 596- 604 ,(2010) , 10.1038/ICB.2010.9
Alexandra M. Livingstone, Marina Kuhn, Peptide-pulsed splenic dendritic cells prime long-lasting CD8+ T cell memory in the absence of cross-priming by host APC European Journal of Immunology. ,vol. 32, pp. 281- 290 ,(2002) , 10.1002/1521-4141(200201)32:1<281::AID-IMMU281>3.0.CO;2-P
Zhengrong Cui, Fu Qiu, CD4+ T helper cell response is required for memory in CD8+ T lymphocytes induced by a poly(I:C)-adjuvanted MHC I-restricted peptide epitope. Journal of Immunotherapy. ,vol. 30, pp. 180- 189 ,(2007) , 10.1097/01.CJI.0000211330.61019.6F
Meora Feinmesser, Elimelech Okon, Ariel Schwartz, Ella Kaganovsky, Britta Hardy, Elena Aminov, Ben Nageris, Jaqueline Sulkes, Raphael Feinmesser, Histologic and immunohistochemical characterization of tumor and inflammatory infiltrates in oral squamous cell carcinomas treated with local multikine immunotherapy: the macrophage at the front line European Archives of Oto-rhino-laryngology. ,vol. 261, pp. 359- 368 ,(2004) , 10.1007/S00405-003-0615-X
Oliver Schulz, Sandra S. Diebold, Margaret Chen, Tanja I. Näslund, Martijn A. Nolte, Lena Alexopoulou, Yasu-Taka Azuma, Richard A. Flavell, Peter Liljeström, Caetano Reis e Sousa, Toll-like receptor 3 promotes cross-priming to virus-infected cells Nature. ,vol. 433, pp. 887- 892 ,(2005) , 10.1038/NATURE03326
Vincenzo Bronte, Paolo Serafini, Elisa Apolloni, Paola Zanovello, Tumor-induced immune dysfunctions caused by myeloid suppressor cells. Journal of Immunotherapy. ,vol. 24, pp. 431- 446 ,(2001) , 10.1097/00002371-200111000-00001
Jennifer M. Reiman, Maciej Kmieciak, Masoud H. Manjili, Keith L. Knutson, Tumor immunoediting and immunosculpting pathways to cancer progression. Seminars in Cancer Biology. ,vol. 17, pp. 275- 287 ,(2007) , 10.1016/J.SEMCANCER.2007.06.009
Mohamed L Salem, Andre N Kadima, David J Cole, William E Gillanders, None, Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity Journal of Immunotherapy. ,vol. 28, pp. 220- 228 ,(2005) , 10.1097/01.CJI.0000156828.75196.0D
H. Navabi, B. Jasani, A. Reece, A. Clayton, Z. Tabi, C. Donninger, M. Mason, M. Adams, A clinical grade poly I:C-analogue (Ampligen®) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro Vaccine. ,vol. 27, pp. 107- 115 ,(2009) , 10.1016/J.VACCINE.2008.10.024