Compositions comprising apomorphine and organic acids and uses thereof

作者: Oron Yacoby-Zeevi , Mara Nemas

DOI:

关键词:

摘要: The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly composition comprising apomorphine and an organic acid, which are useful in treatment neurological movement diseases disorders, e.g., Parkinson's disease, conditions associated therewith.

参考文章(89)
Enrico Redenti, Lajos Szente, Josef Szejtli, Cyclodextrin complexes of salts of acidic drugs. Thermodynamic properties, structural features, and pharmaceutical applications. Journal of Pharmaceutical Sciences. ,vol. 90, pp. 979- 986 ,(2001) , 10.1002/JPS.1050
Ming-Jun Tsai, Yaw-Bin Huang, Pao-Chu Wu, Yaw-Syan Fu, Yao-Ren Kao, Jia-You Fang, Yi-Hung Tsai, Oral Apomorphine Delivery from Solid Lipid Nanoparticles with Different Monostearate Emulsifiers: Pharmacokinetic and Behavioral Evaluations Journal of Pharmaceutical Sciences. ,vol. 100, pp. 547- 557 ,(2011) , 10.1002/JPS.22285
Donald R. Mehlisch, Alfredo Ardia, Teresa Pallotta, A controlled comparative study of ibuprofen arginate versus conventional ibuprofen in the treatment of postoperative dental pain. The Journal of Clinical Pharmacology. ,vol. 42, pp. 904- 911 ,(2002) , 10.1177/009127002401102821
Xavier Gomis, Patrick Aloy, Albert Pujol, Baldomero Oliva, Alberto Lleó, Mireia Coma, José Manuel Mas, Combination therapies for treating neurological disorders ,(2012)
Mollie Gordon, Joanne Markham, Johanna M. Hartlein, Jonathan M. Koller, Susan Loftin, Kevin J. Black, Intravenous levodopa administration in humans based on a two-compartment kinetic model. Journal of Neuroscience Methods. ,vol. 159, pp. 300- 307 ,(2007) , 10.1016/J.JNEUMETH.2006.07.010
Beatriz Pardo, María Angeles Mena, Stanley Fahn, Justo García de Yébenes, Ascorbic acid protects against levodopa‐induced neurotoxicity on a catecholamine‐rich human neuroblastoma cell line Movement Disorders. ,vol. 8, pp. 278- 284 ,(1993) , 10.1002/MDS.870080305
John G. Nutt, Julie H. Carter, Eric S. Lea, William R. Woodward, Motor fluctuations during continuous levodopa infusions in patients with Parkinson's disease Movement Disorders. ,vol. 12, pp. 285- 292 ,(1997) , 10.1002/MDS.870120304
A. Hirano, T. Arakawa, K. Shiraki, Arginine increases the solubility of coumarin: comparison with salting-in and salting-out additives. Journal of Biochemistry. ,vol. 144, pp. 363- 369 ,(2008) , 10.1093/JB/MVN078
M. J. Steiger, F. Stocchi, A. Carta, S. Ruggieri, A. Agnoli, N. P. Quinn, C. D. Marsden, The Clinical Efficacy of Oral Levodopa Methyl Ester Solution in Reversing Afternoon “Off” Periods in Parkinsonʼs Disease Clinical Neuropharmacology. ,vol. 14, pp. 241- 244 ,(1991) , 10.1097/00002826-199106000-00007