The clonal and mutational evolution spectrum of primary triple-negative breast cancers
作者： Sohrab P Shah , Andrew Roth , Rodrigo Goya , Arusha Oloumi , Gavin Ha
DOI: 10.1038/NATURE10933
关键词:
摘要: Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having only a handful of coding somatic aberrations in a few pathways, whereas others contain hundreds of coding somatic mutations. High-throughput RNA sequencing (RNA …
nature.com
harvard.edu
curtin.edu.au
mdc-berlin.de
researchgate.net 参考文章(23)
Anne-Lise Børresen-Dale, TP53 and breast cancer Human Mutation. ,vol. 21, pp. 292- 300 ,(2003) , 10.1002/HUMU.10174
A. H. Wyllie, D. J. Adams, M. J. Arends, G. Poulogiannis, R. E. McIntyre, M. Dimitriadi, J. R. Apps, C. H. Wilson, K. Ichimura, F. Luo, L. C. Cantley, PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 15145- 15150 ,(2010) , 10.1073/PNAS.1009941107
Ryan D Morin, Maria Mendez-Lago, Andrew J Mungall, Rodrigo Goya, Karen L Mungall, Richard D Corbett, Nathalie A Johnson, Tesa M Severson, Readman Chiu, Matthew Field, Shaun Jackman, Martin Krzywinski, David W Scott, Diane L Trinh, Jessica Tamura-Wells, Sa Li, Marlo R Firme, Sanja Rogic, Malachi Griffith, Susanna Chan, Oleksandr Yakovenko, Irmtraud M Meyer, Eric Y Zhao, Duane Smailus, Michelle Moksa, Suganthi Chittaranjan, Lisa Rimsza, Angela Brooks-Wilson, John J Spinelli, Susana Ben-Neriah, Barbara Meissner, Bruce Woolcock, Merrill Boyle, Helen McDonald, Angela Tam, Yongjun Zhao, Allen Delaney, Thomas Zeng, Kane Tse, Yaron Butterfield, Inanç Birol, Rob Holt, Jacqueline Schein, Douglas E Horsman, Richard Moore, Steven JM Jones, Joseph M Connors, Martin Hirst, Randy D Gascoyne, Marco A Marra, None, Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma Nature. ,vol. 476, pp. 298- 303 ,(2011) , 10.1038/NATURE10351
N. Agrawal, M. J. Frederick, C. R. Pickering, C. Bettegowda, K. Chang, R. J. Li, C. Fakhry, T.-X. Xie, J. Zhang, J. Wang, N. Zhang, A. K. El-Naggar, S. A. Jasser, J. N. Weinstein, L. Trevino, J. A. Drummond, D. M. Muzny, Y. Wu, L. D. Wood, R. H. Hruban, W. H. Westra, W. M. Koch, J. A. Califano, R. A. Gibbs, D. Sidransky, B. Vogelstein, V. E. Velculescu, N. Papadopoulos, D. A. Wheeler, K. W. Kinzler, J. N. Myers, Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 Science. ,vol. 333, pp. 1154- 1157 ,(2011) , 10.1126/SCIENCE.1206923
Sohrab P Shah, Ryan D Morin, Jaswinder Khattra, Leah Prentice, Trevor Pugh, Angela Burleigh, Allen Delaney, Karen Gelmon, Ryan Guliany, Janine Senz, Christian Steidl, Robert A Holt, Steven Jones, Mark Sun, Gillian Leung, Richard Moore, Tesa Severson, Greg A Taylor, Andrew E Teschendorff, Kane Tse, Gulisa Turashvili, Richard Varhol, René L Warren, Peter Watson, Yongjun Zhao, Carlos Caldas, David Huntsman, Martin Hirst, Marco A Marra, Samuel Aparicio, None, Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution Nature. ,vol. 461, pp. 809- 813 ,(2009) , 10.1038/NATURE08489
Christina Curtis, Sohrab P Shah, Suet-Feung Chin, Gulisa Turashvili, Oscar M Rueda, Mark J Dunning, Doug Speed, Andy G Lynch, Shamith Samarajiwa, Yinyin Yuan, Stefan Gräf, Gavin Ha, Gholamreza Haffari, Ali Bashashati, Roslin Russell, Steven McKinney, METABRIC Group Co-chairs Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 c, Writing committee Curtis† Christina 15 16 Shah Sohrab P. 17 18 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 e, Steering committee Brenton James D. 15 16 Ellis Ian 19 Huntsman David 17 18 Pinder Sarah 20 Purushotham Arnie 20 Murphy Leigh 21 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 j, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Chia Steven 18 Gelmon Karen 18 Huntsman David 17 18 McKinney Steven 17 18 Speers Caroline 18 Turashvili Gulisa 17 18 Watson Peter 17 18 21, University of Nottingham Ellis Ian 19 Blamey Roger 19 Green Andrew 19 Macmillan Douglas 19 Rakha Emad 19, King’s College London Purushotham Arnie 20 Gillett Cheryl 20 Grigoriadis Anita 20 Pinder Sarah 20 de Rinaldis Emanuele 20 Tutt Andy 20, Manitoba Institute of Cell Biology Murphy Leigh 21 Parisien Michelle 21 Troup Sandra 21, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Turashvili Gulisa 17 18 Bell Lynda 18 Chow Katie 18 Gale Nadia 18 Huntsman David 17 18 Kovalik Maria 18 Ng Ying 18 Prentice Leah 18, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Shah Sohrab P. 17 18 Bashashati Ali 17 Ha Gavin 17 Haffari Gholamreza 17 McKinney Steven 17 18, None, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature. ,vol. 486, pp. 346- 352 ,(2012) , 10.1038/NATURE10983
Anita Langerød, Hongjuan Zhao, Ørnulf Borgan, Jahn M Nesland, Ida RK Bukholm, Tone Ikdahl, Rolf Kåresen, Anne-Lise Børresen-Dale, Stefanie S Jeffrey, TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer. Breast Cancer Research. ,vol. 9, pp. 1- 16 ,(2007) , 10.1186/BCR1675
Guanming Wu, Xin Feng, Lincoln Stein, A human functional protein interaction network and its application to cancer data analysis Genome Biology. ,vol. 11, pp. 1- 23 ,(2010) , 10.1186/GB-2010-11-5-R53
N. Stransky, A. M. Egloff, A. D. Tward, A. D. Kostic, K. Cibulskis, A. Sivachenko, G. V. Kryukov, M. S. Lawrence, C. Sougnez, A. McKenna, E. Shefler, A. H. Ramos, P. Stojanov, S. L. Carter, D. Voet, M. L. Cortes, D. Auclair, M. F. Berger, G. Saksena, C. Guiducci, R. C. Onofrio, M. Parkin, M. Romkes, J. L. Weissfeld, R. R. Seethala, L. Wang, C. Rangel-Escareno, J. C. Fernandez-Lopez, A. Hidalgo-Miranda, J. Melendez-Zajgla, W. Winckler, K. Ardlie, S. B. Gabriel, M. Meyerson, E. S. Lander, G. Getz, T. R. Golub, L. A. Garraway, J. R. Grandis, The Mutational Landscape of Head and Neck Squamous Cell Carcinoma Science. ,vol. 333, pp. 1157- 1160 ,(2011) , 10.1126/SCIENCE.1208130
Graham R. Bignell, Chris D. Greenman, Helen Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathon Hinton, Ciara Fahey, Beiyuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin T. Teh, Panos Deloukas, Fengtang Yang, Peter J. Campbell, P. Andrew Futreal, Michael R. Stratton, Signatures of mutation and selection in the cancer genome Nature. ,vol. 463, pp. 893- 898 ,(2010) , 10.1038/NATURE08768