Amide Proton Transfer MRI Signal as a Surrogate Biomarker of Ischemic Stroke Recovery in Patients With Supportive Treatment

摘要: Background: Amide proton transfer (APT) MR imaging has shown great potential in the evaluation of stroke severity because its sensitivity to acid environments. However, this promising MRI technique not been used assess treatment efficacy with regard recovery. Purpose: To therapeutic effect supportive ischemic patients using pH-sensitive APT technique. Material and Methods: Forty-three at an early stage were recruited scanned conventional sequences 3T before treatment. After treatment, 26 underwent a follow-up scan (one three times on different days). The magnetization-transfer-ratio asymmetry 3.5 ppm, usually called APT-weighted (APTW) signal, was measured. APTW signal changes following analyzed. Results: Baseline intensities infarcted lesions inversely correlated baseline severity. Lesion values gradually increased time 24 cases (92.3%) scan, showing clinical symptom improvements. Two (7.7%) showed further decreased accompanied by aggravation. Compared baseline, significant increases found for all post-treatment (efficacious), whether based or onset times. increase lesion after associated improvement symptoms. Conclusion: would be useful biomarker which