Molecular Imaging of Tumors Using a Quantitative T 1 Mapping Technique via Magnetic Resonance Imaging.

摘要: Magnetic resonance imaging (MRI) of glioblastoma multiforme (GBM) with molecular agents would allow for the specific localization brain tumors. Prior studies using T1-weighted MR demonstrated that SBK2-Tris-(Gd-DOTA)3 agent labeled heterotopic xenograft models tumors more intensely than non-specific contrast conventional techniques. In this study, we used a dynamic quantitative T1 mapping strategy to objectively compare intra-tumoral retention over time in comparison non-targeted control agents. Our results demonstrate targeted agent, scrambled-Tris-(Gd-DOTA)3 and clinical Optimark™ all enhanced flank human glioma cells similar maximal changes on mapping. However, differs. The show significant recovery within 20 min by an increase while is retained shows little 60 min. effect percent change values slope calculations as well gadolinium concentration tumor compared muscle. Quantitative demonstrates superior binding currently use.