Vitiligo Skin Is Imprinted with Resident Memory CD8 T Cells Expressing CXCR3

摘要: Vitiligo is a chronic autoimmune depigmenting skin disorder that results from loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with prominent role the immune system, particular T cells. After repigmentation, vitiligo frequently recurs same area, suggesting could involve presence resident memory cells (TRM). We sought to perform thorough characterization phenotype and function vitiligo. show stable active perilesional enriched population CD8 TRM expressing both CD69 CD103 compared psoriasis control unaffected skin. are mainly localized epidermis. Expression CXCR3 observed on most vitiligo, including melanocyte-specific displayed increased production IFN-γ tumor necrosis factor-α moderate cytotoxic activity. Our study highlights functional reinforcing concept as an disease. The remain play during flares, emphasizing interest targeting this cell subset