Studies on Leukemia Development in the SJL/J Strain of Mice

摘要: Spontaneous reticulum cell neoplasms developed in 70-80% of intact male and female SJL/J mice at a mean age 380 days. The had basic histological pattern multicellular type-B neoplasm, as designated by Dunn. tumors were transplanted isogenic mice. Serial passages suspensions these carried on through least 4 tumor-inducing generations, the growing maintained structure neoplasm similar to original tumor. A survey spontaneous lesions revealed different characteristics neoplasms, some Hodgkin's lesions. Five or ten feedings 7,12-dimethylbenz-[alpha]anthracene (DMBA) polyethylene glycol 400 (1 mg DMBA per feeding) induced lymphosarcomas 74-83% 157-188 single feeding only 27% 246 These DMBA-induced lymphatic leukemias do not appear depend thymus for development--a 60% incidence was obtained adult thymectomized treated with DMBA, DMBA-treated myeloid leukemia 180 Urethan slightly leukemogenic