Effects of Epidermal Growth Factor Receptor Concentration on Tumorigenicity of A431 Cells in Nude Mice
作者： Carol L. MacLeod , June B. Santon , Gordon N. Gill , Hideo Masui , John Mendelsohn
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摘要: To test the relationship between concentration of epidermal growth factor (EGF) receptors and tumor in vivo, we measured rate several independently isolated A431 cell lines athymic mice. This series clonal variants with differing extents EGF receptor gene amplification protein expression were implanted into mice time to solid formation measured. Results these experiments indicate that degree are directly correlated cells as tumors host animals. Complementary DNA hybridization analysis revealed no change extent versus excised nor any evidence further rearrangement vivo. A high appears facilitate vivo vitro.
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