Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome).

摘要: Glial cytoplasmic inclusions (GCIs) were demonstrated by silver staining, immunocytochemistry and electron microscopy in the central nervous system (CNS) of 11 patients with various combinations striatonigral degeneration, olivopontocerebellar atrophy Shy-Drager syndrome. Although their configuration light microscope can sometimes resemble neurofibrillary tangles, cellular localisation, measurements, ultrastructure, immunocytochemical characteristics regional distribution all differ from these Alzheimer type changes. The majority GCIs localized white matter appeared to be accompanied an increase number interfascicular oligodendroglial cells pallor or loss myelin staining. Our histological, ultrastructural findings indicate that which contain are oligodendrocytes themselves composed tubular structures. presence until now unknown CNS, but not age- sex-matched control brains, indicates GCI is a change characteristic multiple three syndromes manifestations same disease.