Revisit the Candidacy of Brain Cell Types as the Cell(s) of Origin for Human High-Grade Glioma.

摘要: High-grade glioma, particularly, glioblastoma, is the most aggressive cancer of central nervous system (CNS) in adults. Due to its heterogeneous nature, glioblastoma almost inevitably relapses after surgical resection and radio-/chemotherapy, thus highly lethal associated with a dismal prognosis. Identifying cell origin has been considered an important aspect understanding tumor heterogeneity, thereby holding great promise designing novel therapeutic strategies for glioblastoma. Taking advantage genetic lineage-tracing techniques, performed mainly on genetically engineered mouse models (GEMMs), multiple types CNS have suggested as potential cells among which adult neural stem (NSCs) oligodendrocyte precursor (OPCs) are major candidates. However, it remains debated whether these equally capable transforming patients, given that human brain, some divide so slowly, therefore may never chance transform. With recent advances studying NSCs OPCs, particularly from perspective comparative biology, we now realize notable differences exist mammalian species. These critical impacts shaping our glioma humans. In this perspective, update current progress field clarify misconceptions inputs findings about biology OPCs. We propose re-evaluate cellular candidacy cells, emphasis studies between animal