Accelerated NaCl-induced hypertension in taurine-deficient rat: role of renal function.

摘要: Taurine modulates blood pressure and renal function. As the kidney plays a pivotal role in long-term control of arterial pressure, we tested hypothesis that taurine-deficient rats display maladaptive responses to uninephrectomy. Control (i.e., beta-alanine-treated) with either one or two remaining kidneys were fed diets containing basal high (8%) NaCl diet. Urine osmolality was greater than controls normal diet; proteinuria unaffected by Following 6 weeks on an 8% diet, uninephrectomized (UNX) animals developed significant hypertension, which more severe group; baroreflex function unaffected. However, UNX displayed impaired ability dispose acute isotonic saline volume load before switchover Nonetheless, protracted exposure 14 weeks) dietary excess eliminated differential between groups; at this stage, excretory atrial natriuretic peptide similar groups. hypertensive proteinuria, although both groups excreted proteins molecular weights ( approximately 15-66 kDa). Further, specimens periarterial mononuclear cell infiltrates strong immunoreactivity histiocyte marker CD68, suggestive increased phagocytic activity. In conclusion, taurine deficiency adaptation combined uninephrectomy excess, resulting accelerated development hypertension.