Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury

摘要: Taurine possesses membrane stabilization, osmoregulatory and antioxidant properties, aspects of relevance to ischemic injury. We tested the hypothesis that body taurine status is a determinant renal Accordingly, function structure were examined in control (C), taurine-treated (TT) deficient (TD) rats subjected bilateral ischemia (60 min) followed by reperfusion (IR); sham operated served as controls. Baseline urine osmolality was greater TD group than TT groups, an effect associated with increased aquaporin 2 level. The IR insult reduced (i.e., day-1 post insult); TD/IR displayed more marked recovery day-6 other two groups. Fluid sodium excretions lower group, suggesting propensity retention. Histopathological examination revealed presence tubular necrotic foci C/IR While architecture showed features resembling controls, TT/IR dilated tubules, which lacked immunostaining for 2, but not 1, suggestive proximal tubule origin. Finally, assessment cell proliferation apoptosis higher apoptotic Collectively, results indicate major