Antibodies to high-density lipoproteins are associated with inflammation and cardiovascular disease in rheumatoid arthritis patients

摘要: Several lines of evidence suggest that chronic inflammation and immune dysregulation are related to altered lipid profiles in rheumatoid arthritis (RA), but the actual mechanisms still unclear. We wondered whether development antibodies against high-density lipoprotein (HDL) can be found RA patients linked clinical cardiovascular (CV) risk factors. To this end, immunoglobulin G (IgG) anti-HDL total IgG serum levels were quantified 212 patients, 131 sex- age-matched healthy controls (HC), 52 subjects with traditional CV factors (tCVRs). A subgroup 13 was prospectively followed on TNFα-blockade. TNFα, interferon (IFN)α, MIP1α, IFNγ, IL-8, VEGF, GM-CSF, IL-17, MCP-1, SDF-1α, resistin, leptin by immunoassays. higher compared HC (P < 0.0001) tCVR = 0.015). Differences remained after correction for 0.003). Anti-HDL/IgG negatively associated HDL (-1.182 [-1.823 -0.541], P 0.0003) adjusting demographical, clinical, inflammatory parameters, treatments. high anti-HDL/IgG (n 40, 18.8%) more likely have experienced a event exhibited increased several proinflammatory mediators (C-reactive protein, IFNα, IL-17 MCP-1). Finally, change TNFα-blockade independently increasing levels. Overall, tCVRs milieu impaired blood profile, which may contribute rate events these patients.