Autoantibodies to C-reactive protein (CRP) and other acute-phase proteins in systemic autoimmune diseases

摘要: Autoantibodies to CRP were reported previously in patients suffering from toxic oil syndrome. This syndrome resembles autoimmune diseases such as systemic lupus erythematosus (SLE) or scleroderma. We therefore examined the prevalence of antibodies and other acute-phase proteins diseases, including SLE, subacute cutaneous (SCLE), scleroderma (SSc), primary biliary cirrhosis (PBC), well bone marrow transplantation-induced chronic graft-versus-host disease eosinophilia-myalgia IgG found 78% SLE 30% SCLE patients, while 16% with PBC positive. In up 45% SSc predominantly ceruloplasmin detectable. Lack involvement discoid localized (morphea) correlated low absent antibody formation. However, no correlation was between anti-acute-phase protein liver organ involvement. Adsorption studies revealed that non-native epitopes on molecule, termed modified CRP, are main target antibodies. Chronic inflammatory tissue injury might increase presentation cryptic threshold required for T cell activation.