Association of the Cyclin D1 A870G Polymorphism With Advanced Colorectal Cancer

摘要: ContextCyclin D1 (CCND1) is a key cell cycle regulatory protein, the overexpression of which often found in human tumors and associated with proliferation and poor prognosis. A common adenine-to-guanine substitution polymorphism (A870G) CCND1 gene results an altered messenger RNA transcript longer-life are preferentially encoded by allele.ObjectiveTo test overall stage-specific associations of 870A allele colorectal cancer.Design, Setting, ParticipantsA population-based case-control study conducted multiethnic population of Hawaii between January 1, 1994, August 31, 1998, included 504 patients incident cancer 624 participants of Japanese, white, or Native Hawaiian origin. Participation rates were 58% for cases 52% for controls.Main Outcome MeasurementEthnicity, gene-dosage effects, stage (regional/distant) subsite (colon vs rectal) cancer.ResultsThe odds ratio (OR) 870 GA and AA genotypes compared GG genotype was 1.2 (95% confidence interval [CI], 0.9-1.7) 1.5 CI, 1.0-2.1), respectively (P = .03 effect). These risk estimates significantly greater patients diagnosed at regional distant (GA GG: OR, 1.7; 95% 1.1-2.5 AA OR, 1.9; 1.2-3.1; P .008 effect) those for patients earlier .048). In subset analyses, association advanced colorectal cancer statistically significant white participants but not stronger rectal cancer.ConclusionThe may be with colorectal cancer, particularly forms disease that result in severe morbidity mortality.