Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck.

摘要: We have previously reported that the cyclin D1 ( CCND1 ) GG 870 genotype was associated with poorly differentiated tumors and reduced disease-free interval in patients squamous cell carcinoma of head neck (SCCHN). now examined association this a second polymorphism gene expression outcome SCCHN patients. Analysis G/C 1722 revealed CC [ P = 0.005; odds ratio (OR), 5.7; 95% CI, 1.7 to 19.2), 0.003; Hazard Ratio (HR), 7.3; 1.1 27.2.) independently from influence genotype. Patients whose were negative for 0.028; HR, 4.1; 1.4 14.2). Although genotypes not expression, we found significant trend between 0.04). Splicing mRNA tissues modulated by A/G alleles, thus transcript spliced equally A G whereas b mainly allele. Our analysis has also identified differences protein pathogenesis males females. Thus, more common female 0.019; OR, 3.3; 1.3 10) frequent (chi-square 1 , 3.96; 0.046) at higher levels 0.004) In summary, our data show two polymorphic sites are tumor biology clinical outcome. alleles affect tissues. provide preliminary evidence molecular genetics development may be influenced patient gender.