Prognostic significance of p53 and ras p21 expression in nonsmall cell lung cancer

摘要: Background. Alterations of the p53 gene are one most common genetic changes in various types cancer, including lung cancer. Abnormalities ras genes, point mutations and overexpression, another feature molecular biology cancer associated with a poorer prognosis. The authors' purpose was to determine expression mutated nonsmall cell (NSCLC) specimens that were studied for p21 document whether altered also an important factor survival. Methods. Ninety-six patients NSCLC underwent surgical resection between 1977 1985, 63 whom received postoperative combination chemotherapy. None radiation therapy. Tumor analyzed by immunohistochemistry. Univariate multivariate analyses performed assess association survival. Results. Fifty-six (58%) 96 tumor showed expression, 91 survival. Altered did not correlate clinicopathologic characteristics except postsurgical pathologic (pT) classification. survived significantly shorter period after surgery than those without all who potentially curative (P = 0.02 P 0.048, respectively, generalized [Wilcoxon test]. Multivariate analysis independent prognostic significance (hazard ratio [HR] 1.72, 0.04) cure (HR 4.69, < 0.001). combined same revealed p53- p21-negative tumors longest among different features 0.005, Wilcoxon test). Conclusion. is significant negative surgically resected NSCLC. Combined immunohistochemical can divide into more accurate groups. If current findings be confirmed larger prospective studies, useful clinical tool stratifying groups identifying population risk recurrence.