Leptin therapy, insulin sensitivity, and glucose homeostasis

摘要: Glucose homeostasis is closely regulated not only by insulin, but also leptin. Both hormones act centrally, regulating food intake and adiposity in humans. Leptin has several effects on the glucose-insulin homeostasis, some of which are independent body weight adiposity. Those leptin determined centrally hypothalamus peripherally pancreas, muscles liver. beneficial metabolism, decreasing glycemia, insulinemia insulin resistance. The understanding will lead to development leptin-based therapies against diabetes other resistance syndromes. In these review, we summarize interactions between their glucose metabolism.