Incidence and characteristics of biphasic reactions after allergen immunotherapy

摘要: Background The reported incidence of biphasic anaphylactic reactions varies from 1% to 20%. Reported risk factors for include a delay in epinephrine administration and longer interval initial improvement. To date, only 4 cases after allergen immunotherapy have been reported. Objective We sought determine the incidence, clinical characteristics, allergen-specific immunotherapy. Methods Patients who were treated with systemic prospectively enrolled. assessed initially at 24 hours by using 31-symptom scoring system. Results Sixty occurred 55 patients; 14 (23%) experiencing more likely be female (P = .03) older .01) require greater than 1 dose .001). There was no difference between groups (biphasic vs reaction) regarding type immunotherapy, current asthma, symptom scores, or time symptoms, epinephrine, No specific predicted reactions. Biphasic significantly less severe compared reaction Conclusions Twenty-three percent patients requiring caused experienced symptoms. promptly should cautioned reactions; however, mild did not additional epinephrine.