Hepatocytes response to interferon alpha levels recorded after liver resection.

摘要: Extensive damage of liver parenchyma stimulates hepatic cells to transit from quiescence proliferation with eventual restoration mass and function. Our recent studies have revealed upregulated expression interferon (IFN)-α its antiviral activity during the early hours after partial hepatectomy. In this study, we analyzed response primary hepatocytes intact IFN-α mimicking levels (250 U/mL) transition period restoration. The gene profile was rat genome array 230 2.0 (Affymetrix). After 3- 6-h treatment identified respectively 28 124 differentially expressed genes responsible for autonomous changes in those involving non-parenchymal a concerted IFN-α. has an energy sparing character affects all expression. factors activating T apoptosis are opposed by restricting signal propagation, inhibiting activation, ...