The Role of the Estrogen Receptor in Uterine Epithelial Proliferation and Cytodifferentiation in Neonatal Mice
作者： SHUJI YAMASHITA , RETHA R. NEWBOLD , JOHN A. McLACHLAN , KENNETH S. KORACH
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摘要: We have examined the relationship between localization of estrogen receptor (ER) and selected cell responses induced by in neonatal CD-I mouse uterus. The following simultaneous staining techniques were used to determine whether only uterine epithelial cells with ER are capable showing proliferative secretory activities after treatment: 1) [3H]thymidine incorporation using immunohistochemistry autoradiography; 2) immunohistochemical double an estrogeninduced protein lactoferrin (LF). Uterine tissues from two strains (CD-I BALB/c) mice on day 4 age showed detectable immunostaining both stromal cells. Day received a single injection diethylstilbestrol (DES; 20 μg/kg BW). percentage ER-immunostained intensity rapidly increased 6–36 h, indicating that stimulates expression detectability during the...
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