Expansion of Anti-Mesothelin Specific CD4+ and CD8+ T Cell Responses in Patients with Pancreatic Carcinoma

摘要: We aimed to assess the status of naturally occurring CD4(+) and CD8(+) T cell responses a tumour associated antigen, Mesothelin, in patients with pancreatic carcinoma study effects elevated IL-10 on Mesothelin-specific responses. For that sake, short term lines were generated from PBMCs 16 healthy controls, 15 benign diseases 25 analysed using intracellular cytokine assays for IFN-γ. Plasma levels Mesothelin measured cytometric bead array ELISA assay, respectively. The blocking performed Here, we demonstrate plasma are significantly increased carcinoma. Additionally, found (a) expanded cancer (p = 0.0053), (b) multifunctional response is directed toward broad repertoire epitopes within protein. (c) CD4+ directly inhibited by patients. These data provides evidence use as an immunogen tumour-specific response.