CSF protein examinations with thin-layer isoelectric focusing in multiple sclerosis

摘要: Abstract Thin-layer IEF, due to its extremely high resolving capacity, has been found be quite valuable for CSF protein examinations, one important advantage of the technique being excellent capacity separation immunoglobulins. The and serum proteins 230 patients with clinically verified or probable MS 20 subjects optic neuritis were examined thin-layer IEF findings compared clinical data results other examinations. All but 3 about two thirds exhibited combinations different aberrations in acidic alkaline range. Oligoclonal bands and/or regional increases Ig fractions, changes compatible intrathecal synthesis, detected respectively 95 80% 30% neuritis. Other aberrant fractions (including transferrin, taufraction gamma-trace protein) half cases; some these had highest occurrence most extensive abnormalities. diverse seemed influenced by duration course disorder as well sites lesions; further factors might release decomposition products from destroyed tissues, genetically determined reactivity individual presence possible agents.