作者: Claude Condé , Geoffrey Gloire , Jacques Piette
DOI: 10.1016/J.BCP.2011.05.031
关键词:
摘要: PI3K cascade is a central signaling pathway regulating cell proliferation, growth, differentiation, and survival. Tight regulation of the necessary to avoid aberrant proliferation cancer development. Together with SHIP-1, inositol phosphatases PTEN SHIP-2 are gatekeepers this pathway. In review, we will focus on SHIP-1 functions. Negative immune activation by well characterized. Besides its catalytic activity, also displays non-enzymatic activity playing role in several pathways. Indeed, exhibits domains that mediate protein-protein interaction. This review emphasizes negative mediated