Differentiation of green fluorescent protein-labeled embryonic stem cell-derived neural precursor cells into Thy-1-positive neurons and glia after transplantation into adult rat striatum
作者： Stefan Arnhold , Doris Lenartz , Klaus Kruttwig , Franz-Josef Klinz , Eugen Kolossov
DOI: 10.3171/JNS.2000.93.6.1026
关键词:
摘要: Object. The aim of this investigation was to assess new information concerning the capacity transplanted embryonic stem cell (ESC)-derived neuronal cells migrate into host brain and evaluate these as a possible source for replacement therapy in neurodegenerative disorders such Parkinson's disease (PD). Methods. authors investigated ability ESC-derived neural precursor differentiate striatum by using D3-derived ESC clone that transfected stably with chicken β-actin cytomegalovirus enhancer—driven green fluorescent protein (GFP)-labeled construct. This procedure allowed easy monitoring all because labeling donor cells. approach also afforded estimation integration simultaneous observation entire population relation immunocytochemically identified glial differentiation. After selection nestin-positive c...
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