HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: Analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years
作者： Toshio Matsuzaki , Masanori Nakagawa , Masahiro Nagai , Koichiro Usuku , Itsuro Higuchi
DOI: 10.1080/13550280152403272
关键词:
摘要: To clarify clinical and laboratory findings that may be related to the pathomechanism of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed these in 239 patients with HAM/TSP, including 64 followed up for 10 years after their first examinations, special interest HTLV-I proviral load peripheral blood mononuclear cells (PBMCs). The PBMCs did not differ terms modes transmission. However, age disease onset greater than 65 tended higher those a younger onset. In years, symptoms deteriorated 36 (56%), unchanged 26 (41%), improved 2 (3%). also appeared deterioration motor disability patients. our knowledge, present study is longitudinal concerning relationship between course HAM/TSP load. It suggested progression an important factor predict prognosis HAM/TSP.
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