Nasal bone evaluation in fetuses with Down syndrome during the second and third trimesters of pregnancy.
作者： Wesley Lee , Greggory R. DeVore , Christine H. Comstock , Karim D. Kalache , Beverley McNie
关键词:
摘要: Objective. This study examined the use of three-dimensional ultrasonography for evaluating fetal nasal bone, as a sonographic marker Down syndrome, during second and early third trimesters pregnancy. Methods. Forty fetuses, including 20 with trisomy 21, were scanned once by threedimensional ultrasonography. A midline sagittal view facial profile was used to analyze volume data. Independent examiners reviewed blinded randomly allocated data sets bone. Interobserver reliability evaluated presence or absence Logistic regression determined contribution this parameter syndrome. Results. Both showed substantial agreement in scoring whether bone visualized (P < .001). They identified 40% 45% fetuses abnormalities using marker. However, number also found have present. The 80% 90% without abnormalities. Conclusions. Three-dimensional can be evaluate interobserver nonvisualized syndrome study. Key words: fetus; bone; prenatal diagnosis; ultrasonography; 21.
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