Frequent microsatellite instability in non-Hodgkin lymphomas irresponsive to chemotherapy

摘要: Microsatellite instability (MSI) in haematopoietic malignancies has been controversial. Particularly non-Hodgkin lymphoma, the data published to date lack unity. Using a unique fluorescent technique, we found MSI eight (14%) tumours panel of 59 carefully selected lymphoma patients. Our technique also reveals two qualitatively distinct modes MSI, i.e. Type A and B. Based on our previous studies using DNA mismatch repair (MMR) gene-knock out animals, have concluded that is direct consequence defective MMR. observed lymphomas was uniformly A, which implies MMR deficiency occurs this malignancy. Intriguingly, patients treated by CHOP/VEPA-based therapies, response chemotherapy significantly worse those with microsatellite-unstable (p = 0.027). As consequence, patient outcomes at 1 year after treatment were less favourable population 0.046), although survival difference not statistically confirmed longer term. These findings suggest some may lead drug resistance tumour cells and, consequently, poor outcomes. In be potential biomarker predicts against chemotherapy.