Metabolic Profiling Analysis of the Alleviation Effect of Treatment with Baicalin on Cinnabar Induced Toxicity in Rats Urine and Serum.
作者： Guangyue Su , Gang Chen , Xiao An , Haifeng Wang , Yue-Hu Pei
关键词:
摘要: Objectives: Baicalin is the main bioactive flavonoid constituent isolated from Scutellaria baicalensis Georgi. The mechanisms of protection of liver remain unclear. In this study, 1 H NMR-…
frontiersin.org
core.ac.uk 
sci-hub.se 参考文章(25)
Parames C. Sil, Kahkashan Rashid, Joydeep Das, Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food and Chemical Toxicology. ,vol. 51, pp. 317- 329 ,(2013) , 10.1016/J.FCT.2012.10.007
Jeeyoun Jung, Minhwa Park, Hye Jin Park, Sun Bo Shim, Yang Ha Cho, Jinho Kim, Ho-Sub Lee, Do Hyun Ryu, Donwoong Choi, Geum-Sook Hwang, 1H NMR-based metabolic profiling of naproxen-induced toxicity in rats Toxicology Letters. ,vol. 200, pp. 1- 7 ,(2011) , 10.1016/J.TOXLET.2010.09.020
Heesung Chung, Hack Sun Choi, Eun-Kyoung Seo, Duk-Hee Kang, Eok-Soo Oh, Baicalin and baicalein inhibit transforming growth factor-β1-mediated epithelial-mesenchymal transition in human breast epithelial cells Biochemical and Biophysical Research Communications. ,vol. 458, pp. 707- 713 ,(2015) , 10.1016/J.BBRC.2015.02.032
Hong Sun, Qing-Ming Che, Xin Zhao, Xiao-Ping Pu, Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats. European Journal of Pharmacology. ,vol. 631, pp. 53- 60 ,(2010) , 10.1016/J.EJPHAR.2010.01.002
E. M. Lenz, J. Bright, R. Knight, F. R. Westwood, D. Davies, H. Major, I. D. Wilson, Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat Biomarkers. ,vol. 10, pp. 173- 187 ,(2005) , 10.1080/13547500500094034
Qi Wang, Xiaoda Yang, Baoxu Zhang, Xiuwei Yang, Kui Wang, The anxiolytic effect of cinnabar involves changes of serotonin levels European Journal of Pharmacology. ,vol. 565, pp. 132- 137 ,(2007) , 10.1016/J.EJPHAR.2007.03.018
John C. Lindon, Elaine Holmes, Mary E. Bollard, Elizabeth G. Stanley, Jeremy K. Nicholson, Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis Biomarkers. ,vol. 9, pp. 1- 31 ,(2004) , 10.1080/13547500410001668379
Changfeng Hu, Yiqi Wang, Yongsheng Fan, Haichang Li, Chunyan Wang, Jida Zhang, Shuijuan Zhang, Xianlin Han, Chengping Wen, Lipidomics Revealed Idiopathic Pulmonary Fibrosis-Induced Hepatic Lipid Disorders Corrected with Treatment of Baicalin in a Murine Model Aaps Journal. ,vol. 17, pp. 711- 722 ,(2015) , 10.1208/S12248-014-9714-4
Yan Xu, Yunchao Feng, Hailing Li, Zhonghong Gao, Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin. Food and Chemical Toxicology. ,vol. 50, pp. 3264- 3272 ,(2012) , 10.1016/J.FCT.2012.05.061
Min Feng, Min Zhao, Yinan Wang, Shiyi Xu, Miao Wang, Chunjie Zhao, 1H-NMR metabonomics study of the therapeutic mechanism of total alkaloids and ajmalicine from Rauvolfia verticillata in spontaneously hypertensive rats Analytical Methods. ,vol. 6, pp. 6473- 6482 ,(2014) , 10.1039/C4AY00851K