Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients

摘要: Renal transplant recipients (RTRs) are known to have a high cardio-vascular disease (CVD) burden only partly explained by traditional CVD risk factors. The aim of this paper was therefore determine: i) the prognostic value autoantibodies against apoA-1 (anti-apoA-1 IgG) for incidence mortality, all-cause mortality and graft failure in RTR. Four hundred sixty two (462) prospectively included RTRs were followed 7.0 years. Baseline anti-apoA-1 IgG determined associations with (n = 48), 92) 39) tested. Kaplan-Meier analyses demonstrated significant between tertiles (log rank test: p 0.048). Adjusted Cox regression analysis showed 54% increase each levels standard deviation (hazard ratio [HR]: 1.54, 95% Confidence Interval [95%CI]: 1.14-2.05, 0.005), 33% (HR: 1.33; 95%CI: 1.06-1.67, 0.01), independent factors, renal function HDL function. association disappeared after excluding cases specific mortality. sensitivity, specificity, positive predictive value, negative positivity 18.0%, 89.3%, 17.0%, 90.0%, respectively. functionality not associated levels. This prospective study demonstrates that RTR, predictors functionality.