摘要: Clonal deletion of autoreactive T cells in the thymus is not sole mechanism for induction tolerance to self-antigens since partial depletion peripheral CD4 ' from neonatal and adult animals results development organ-specific autoimmunity. Reconstitution these immunodeficient with populations regulatory prevents The lineage generated can be dis- tinguished effector by expression unique membrane antigens. target antigens suppressor their mechanisms action remain poorly defined. Depletion may useful immunity weak antigens, such as tumor-specific Conversely, enhancement cell function a adjunct therapy autoimmune diseases prevention allograft rejection.
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